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Anales de la Facultad de Ciencias Médicas (Asunción)

versão impressa ISSN 1816-8949


LACARRUBBA TALIA, JM  e  CENTRO MATERNO INFANTIL. HOSPITAL DE CLINICAS. FCM-UNA.. Unidad de Cuidados Intensivos Neonatales, Departamento de Noenatologia de la Cátedra y Servicio de Pediatria. Clinical evaluation of the use of two surfactants in premature with respiratory distress disease: 8 years experience. An. Fac. Cienc. Méd. (Asunción) [online]. 2010, vol.43, n.2, pp.19-30. ISSN 1816-8949.

ABSTRACT Introduction: the use of surfactant in preterm infants with respiratory distress is widespread and widely known to improve oxygenation, reduce complications related to air leak and mortality. Objective: to evaluate the impact of two different surfactants, one synthetic and the other natural, on oxygenation during the first 48 hours in infants with severe distress ON mechanical ventilation. Patients and methods: retrospective observational cohort study. We studied 111 neonates less than 34 weeks with a diagnosis of severe distress treated with surfactant in the NICU from 2001 to 2008. We compared the rates of oxygenation of the group receiving synthetic surfactant versus those receiving natural surfactant. The Student t test with a significance level of 0,05 was used. Results: 40 infants received synthetic surfactant and 58 received natural surfactants. Mean gestational age was 32 and 30 weeks respectively, the birth weight was: 1550 and 1300 g. Both groups had the same degree of respiratory failure before receiving the first doses of surfactant. The response was favorable in both groups, but the natural surfactant treated group had a faster improvement in oxygenation, (p<0.01) less need for repeat dose (p<0.01), and a tendency to less time on mechanical ventilation and lower mortality, although not statistically significant. Conclusion: natural surfactant has a faster effect than synthetic surfactant in improving oxygenation in preterm infants with respiratory distress. Keywords: pulmonary surfactant, premature infant, hyaline membrane disease

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