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Anales de la Facultad de Ciencias Médicas (Asunción)

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MARTINEZ BARRIOS, E; BORTOLATTO, L; ALONSO GUTIERREZ, R  and  AMARILLA RAMIREZ, C. Gastrointestinal Stromal Tumors. Radiological Case Report. An. Fac. Cienc. Méd. (Asunción) [online]. 2010, vol.43, n.1, pp.51-56. ISSN 1816-8949.

Gastrointestinal stromal tumor (GIST) represents less than 3% of gastrointestinal malignancies. However, it is the most common mesenchymal tumor of the digestive tract. GIST is characterized by the expression tyrosine kinase CD117, which differentiates it from other mesenchymal tumors such as leiomyomas, leio-miosarcomas, leiomyoblastoma and neurogenic tumors that do not express this protein. 70-80% of the GIST are benign and located mostly in the stomach and small intestine (> 90%).They can also arise from any portion of the digestive tract and mesentery, omentum and retroperitoneum. Malignant GISTs are usually large (> 5 cm), with a high mitotic index, and it can metastasize to the liver and peritoneum. Suggestive findings of computed tomography (CT) are well defined exophytic mass that originates from the wall of the stomach or intestine, which can present hemorrhage, necrosis or cystic component rarely associated with obstruction. The treatment is surgical resection. Good results have been reported with tyrosine kinase inhibitor STI571. The case presented here is a 55 year old woman with a tumor localized in the stomach, treated surgically. The CT study was performed with a 6-detector multislice computer, without and with oral and intravenous contrast. The histopathological examination revealed a GIST,was confirmed by immunohistochemistry. The most important aspects of this tumor is discussed with emphasis on imaging.

Keywords : Gastrointestinal tumor; Stromal tumor; Diagnostic imaging.

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