Abstract

JARA YORG, Jorge Antonio. Treatment of patients with Grave´s disease with ¹³¹I. An. Fac. Cienc. Méd. (Asunción) [online]. 2005, vol.38, n.1-2, pp.38-54. ISSN 1816-8949.

Grave’s disease constitutes the most common thyroid hyperfunction observed whose treatment can be carried out with medication (propiltiouracil, metimazol, etc.), surgery or iodine-131(¹³¹I). We analyzed 70 patients with this type of hyperthyroidism treated with ¹³¹I, in its clinical aspect pre and post treatment, ultrasound and nuclear scan findings of the thyroid gland, the hormonal responds Ft4, T3, TSH, and thyroid antibodies TPOab, TGab, TRab. Besides the diffuse classic image observed in the thyroid scan and by ultrasonography of the gland, in Grave’s disease, 4 types of images were identified with nodules (multinodular, hot nodule, cold nodule and miliar). The group with diffuse increase in size form was the most numerous (50%) continued by the variety multinodular (30%), Marin-Lenhart’s Sindrome (hot nodule) 14%, miliary 3%, and cold nodule 3%. Three months after the treatment with the radioiodine was observed the decrease of the size and thyroid volume in 68% of the patients, thyroid uptake with ¹³¹I diminished in 75%. All patients had an increase of weight of 20% and 87% of then were feminine. The signs and symptoms were normalized in 88,5% of the patients. The levels of FT4 were normalized in 73, 8%, T3 in 66%, TSH in 47,7%, TPOab in 83%, TGab in 90%, and TRab in 84%.A received a single dose of ¹³¹I was used it in 93% of the patient The cost of the ¹³¹I in the Clinic Hospital was half of the cost of the surgery, and at private level the fourth part but cheap.

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