Anales de la Facultad de Ciencias Médicas (Asunción)
versão impressa ISSN 1816-8949
CABRERA CUBILLA, Marta. Clinical expresión and evolution of epilepsy in consanguineous families in a reserved community in the paraguayan Chaco. An. Fac. Cienc. Méd. (Asunción) [online]. 2005, vol.38, n.1-2, pp.29-37. ISSN 1816-8949.
Approximately 1,5% of the world population suffers from epilepsy, which makes it one of the most frequent neurological illness. The epidemiological studies reveal that there are in between 40 to 50 million persons which from epilepsy. Approximately the 40 % present idiopathic generalized epilepsies, up to day a high percentage of them with well demonstrated genetic basis. In the 50 and 60 decades the first studies showed the likely hereditary origin of some of them. With the advanced molecular genetic towards the end of last century, at least 20 genetic mutations have been determined which originate different types of idiopathic epilepsies. In the present descriptive study of transversal cut, clinical characteristic s, the response to treatment and the evolution of partial and generalized idiopathic epilepsies were determined in a reserved community of the Paraguayan Chaco, with ethnic, cultural and religious similar characteristics. With a high component of consanguinity. 28 patients were included with diagnosis of simple, complex and generalized seizures, based on international criteria of classification and diagnosis of seizures, according to the International League of Against Epilepsy. The 82% of patients under study were holders of focal and generalized idiopathic and 14,35% met the characteristic of different subtypes focal and generalized epilepsies, which shows that more than a half are myoclonic epilepsies in adolescents. 100% of them with familiar antecedents of epilepsy show seizures after 20 years of 20 years of age; different subgroup were found in the same family. 90% of diagnosis were corroborated by EEG and 81% were given treatment with one drug, remaining, 90% of them, free of seizures for more than 2 years.