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Memorias del Instituto de Investigaciones en Ciencias de la Salud
On-line version ISSN 1812-9528
Abstract
MEZA, Graciela; SANCHEZ, Zunilda and CERECETTO, Hugo. Potential congenital transmission of Chagas disease in the second generation of young pregnant women who attended prenatal in the department of Cordillera, Paraguay. Mem. Inst. Investig. Cienc. Salud [online]. 2024, vol.22, n.1, e22122404. Epub Apr 29, 2024. ISSN 1812-9528. https://doi.org/10.18004/mem.iics/1812-9528/2024.e22122404.
Trypanosoma cruzi is the causative agent of Chagas disease. In Paraguay, it is estimated that 165,000 people are infected and currently the main route of transmission is the congenital one, with a prevalence of 5% and about 400 infected children are born per year. The Department of Cordillera is an endemic area of the Eastern Region of the country, where the Chagas Prenatal Control Program was implemented in 1995. The aim of this study was to infer the potential congenital transmission of Chagas disease towards second generation pregnant women from the Department of Cordillera who attended their prenatal control in the period 2010-2012, 15 years after the implementation of the Prenatal Control Program. Of 9,588 pregnant women; 482 were seropositive (5%); 2.74% in the group aged 12 to 19 years, 4.93% aged 20 to 30 years, 8.03% aged 31 to 40 years, and 16.11% aged 41 to 48 years. To estimate the origin of second generation congenital transmission, the 72 seropositive women aged 12 to 19 years were taken into account and according to the database of their respective mothers, 61 mothers of the 72 were seropositive. With this información, it can be estimated that 85% of the transmission to second generation pregnant women aged 12 to 19 years was congenital showing a very significant congenital transmission in the study population. This information could help the National Chagas Program in strengthening the control of congenital transmission of Chagas disease in the country.
Keywords : Chagas disease; vertical transmission; congenital Chagas; pregnant women; second generation.
