Abstract

VAZQUEZ-ROA, Sandra Lorena; SOSA-DE SFORZA, Liliana  and  VAZQUEZ-ROA, Alexis. Chronic renal failure by MDRD-4 formula: Prevalence and associated risk factors in Villarrica, Paraguay. Mem. Inst. Investig. Cienc. Salud [online]. 2023, vol.21, n.1, e21122301.  Epub Mar 16, 2023. ISSN 1812-9528.  https://doi.org/10.18004/mem.iics/1812-9528/2023.e21122301.

Chronic renal failure (CRF) contributes to morbidity and mortality of noncommunicable diseases. In Paraguay, the rate of Disability Adjusted Life Years for kidney failure (DALY-IR) increased by more than 50%, substantially increasing the mortality rate. The objective of this study was to determine the prevalence of presumptive CRF (CRFp) applying the MDRD-4 formula in Villarrica, Paraguay, in 2022. The study was a cross-sectional population study in adult residents, apparently healthy, between 19 and 70 years of age, both men and women who agreed to participate through informed consent. A multistage sampling was designed and a final sample of 520 participants was recorded. The reported prevalence was 9.6% (95%CI: 7.4-12.5%), with pCRF hidden in 54% of cases. The study population was mostly young with a mean age of 44 years, overweight with an averange BMI of 28.1 Kg/m2 and 62% of women predominated. A high frequency of urological (40%) and systemic (33%) history was reported. CRFp was associated with: age > 65 years (OR: 3.6), female sex (OR: 2.4), BMI > 25 kg/m2 (OR: 2.7), history of systemic disease (OR: 3.1) and current medication (OR: 3.5). The reported prevalence was consistent with that of the GBD-CKD international research consortium that reported a prevalence of 9.1% for kidney disease according to its global burden. Therefore, the monitoring of associated risk factors must be comprehensively addressed both in diagnosis and in health promotion in order to guarantee quality in public health.

Keywords : epidemiology; renal failure; glomerular filtration.

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