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Memorias del Instituto de Investigaciones en Ciencias de la Salud

On-line version ISSN 1812-9528


FRETES DE AQUINO, Sonia Lorena; LUGO, Gladys; SAMANIEGO, Lourdes  and  DE LARROZA, Mabel Maidana. Comparison of dissolution profiles vs price of national and imported 100 mg potassic losartan tablets, Paraguay (2019). Mem. Inst. Investig. Cienc. Salud [online]. 2021, vol.19, n.3, pp.6-11. ISSN 1812-9528.

Hypertension is the main cardiovascular risk factor, and its prevalence in Paraguay is the highest in Latin America. The objective of the present work was to compare products of 100 mg losartan tablets made in Paraguay and imported products, through dissolution profiles versus price. Eight brands of potassic losartan commercialized during 2017 were subjected to quality controls in accordance with the provisions of the American Pharmacopoeia (USP 38). The percentage of active principle released in the dissolution medium established by USP 38 was determined by means of dissolution profiles. The determinations were made by HPLC and UV/V spectrophotometry. The controls carried out complied with the specifications established by USP 38. No significant differences were found in the statistical analysis of the dissolution profiles of the different brands analyzed. The results showed that the prices of the brands analyzed did not affect the quality of the products, but they affected the cost of treatment of the low-income population due to the higher cost of imported products compared to those of national production.

Keywords : Losartan potassium; arterial hypertension; dissolution profiles.

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