Resumo

MEDINA, Marcelo Gabriel et al. Detection of human papillomavirus in oral mucosa in men with anogenital warts. Mem. Inst. Investig. Cienc. Salud [online]. 2021, vol.19, n.2, pp.41-48. ISSN 1812-9528.  https://doi.org/10.18004/mem.iics/1812-9528/2021.019.02.41.

The human papillomavirus (HPV) is the etiologic agent of sexually transmitted infections related to genital and oral oncogenic processes. Molecular biology provides accurate diagnosis with an epidemiological approach, by identifying the viral types involved. The objective of this study was to determine the presence of HPV in oral mucosa from men with anogenital warts and to correlate the genotypes detected in both samples. Twenty-six male patients suffering anogenital warts who attended to the Institute of Dermatology in Resistencia (Argentina) were studied. The presence of HPV in oral and anogenital samples was studied by PCR and genotyping was performed by PCR-RFLP. The prevalence of oral HPV in patients with anogenital HPV was 46.2% (12/26). Eighteen genotypes with high oncogenic risk were found in oral samples of patients with single or multiple infections and type 16 was the most frequent (6 patients). Fourteen genotypes in oral samples were of low oncogenic risk and the most frequent was type 6 (10 patients). In anogenital samples the genotype 6 was the most frequent (13 patients), alone or in co-infection. A high prevalence of high-grade malignancy oral HPV in our population and co-infection with oncogenic types were found. Oral sex practices were the main risk factor for infection, which was demonstrated by the simultaneous finding of the same HPV type in oral and anogenital samples.

Palavras-chave : HPV; men; anogenital warts; oral mucosa.

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