SciELO - Scientific Electronic Library Online

 
vol.19 número1Resistencia a múltiples antibióticos en serovariedades de Salmonella aisladas de muestras clínicas y alimentosFrecuencia y características clinicopatológicas de mujeres obesas con cáncer de mama del Departamento de Oncología del Hospital de Clínicas índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Memorias del Instituto de Investigaciones en Ciencias de la Salud

versión On-line ISSN 1812-9528

Resumen

PRIETO-CASAL, Fernanda; CABANAS-GADEA, Claudia; FIGUEREDO-LOPEZ, Sonia  y  VILLAGRA-CARRON, Verónica. Fetomaternal immunization against HLA antigens in women from a Paraguayan population. Mem. Inst. Investig. Cienc. Salud [online]. 2021, vol.19, n.1, pp.48-57. ISSN 1812-9528.  https://doi.org/10.18004/mem.iics/1812-9528/2021.019.01.48.

Pregnancy is the only natural cause of immunization against the Human Leukocyte Antigen (HLA) system. During pregnancy, fetal leukocytes pass through the placenta, which can trigger an immunological response in the mother against the fetus paternal HLA antigens, with the consequent production of antibodies. The objective of this study was to determine the prevalence of pregnancy-induced HLA antigen sensitization in Paraguayan women and to study the characteristics and specificities of the antibodies found. We conducted a descriptive, prospective, cross-sectional study of 319 Paraguayan women, who attended the Central Laboratory of Public Health between April 2017 and April 2018 using LUMINEX technology to detect anti-HLA antibodies. We found anti-HLA antibodies in 46% of multiparous women. Antibodies against all tested antigens were detected. The vast majority of the sera exhibited multiple specificities. We conclude that increasing the number of gestations not only increases a woman's likelihood of developing anti-HLA antibodies, but it also appears to increase the number of developed specificities and titers of antibodies.

Palabras clave : anti-HLA antibodies; fetomaternal alloimmunization; immune response; pregnancy.

        · resumen en Español     · texto en Español     · Español ( pdf )