SciELO - Scientific Electronic Library Online

 
vol.17 issue1In vitro synergic activity of the alkaloids Crotsparine and Sparsiflorine, isolated from Croton bomplandianum, against Pseudomonas aeruginosaSimultaneous outbreak of Pseudomonas Aeruginosa and ESBL producing-Klebsiella Pneumoniae in a Neonatal Intensive Care Unit of Asunción, Paraguay author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Memorias del Instituto de Investigaciones en Ciencias de la Salud

On-line version ISSN 1812-9528

Abstract

FERREIRA, Silvia et al. IgA levels in adults with celiac disease. Mem. Inst. Investig. Cienc. Salud [online]. 2019, vol.17, n.1, pp.54-58. ISSN 1812-9528.  http://dx.doi.org/10.18004/mem.iics/1812-9528/2019.017(01)54-058.

Celiac disease (CD) is a systemic autoimmune disease, which is triggered by gluten intake in genetically susceptible individuals. The most important serological markers used for CD diagnosis are test based on immunoglobulin (Ig) A isotype, being the determination of tissue anti-transglutaminase IgA (tTG) 2 the marker of choice for diagnosis. Selective IgA deficiency (SIgAD) is more prevalent in CD patients than in the general population, making the serologically diagnosis of the diseasedifficult. In the present descriptive observational study, 74 adult patients with a confirmed CD diagnosis were included and anti-tTG2 IgA was determined by using ELISA assay in order to detect those patients with undetermined or negative levels, which could present SIgAD. The total IgA level was determined in these patients and the mean concentration was 237.8 ± 100.6 mg/dL. In a female patient, total IgA was less than 7 mg/dL, with normal IgG and IgM levels, characteristic of SIgAD. Thus, the calculated frequency of SIgAD was 1.35% of the CD study population. In conclusion, this work is a first approach to describe the frequency of SIgAD in CD patients of the country and reaffirms the importance of including total IgA determination in the case of conducting IgA-based serological tests specific for CD.

Keywords : Celiac disease; IgA deficiency; autoimmunity.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )