SciELO - Scientific Electronic Library Online

vol.17 issue1Economic development and inequality as factors associated with the prevalence of childhood obesity in ChileIgA levels in adults with celiac disease author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Memorias del Instituto de Investigaciones en Ciencias de la Salud

On-line version ISSN 1812-9528


GARCIA, Javier  and  ALVARENGA, Nelson. In vitro synergic activity of the alkaloids Crotsparine and Sparsiflorine, isolated from Croton bomplandianum, against Pseudomonas aeruginosa. Mem. Inst. Investig. Cienc. Salud [online]. 2019, vol.17, n.1, pp.47-53. ISSN 1812-9528.

The synergistic activity of the alkaloids crotsparine and sparsiflorine, isolated from Croton bomplandianum Baill, was evaluated with the antibacterials gentamicin and ciprofloxacin against Pseudomonas aeruginosa, a microorganism frequently responsible for nosocomial infections. The checkerboard method was used. Combinations were found that had a synergic effect, achieving a reduction of 87.5% of the MIC of gentamicin, while for ciprofloxacin a reduction of 25.0% was observed. This opens interesting perspectives on the combined use of pure natural products and drugs in clinical use for the treatment of infections produced by this microorganism.

Keywords : crotsparine; sparsiflorine; Croton; Pseudomonas; gentamicin; ciprofloxacin.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )