Abstract

GARCIA, Javier  and  ALVARENGA, Nelson. In vitro synergic activity of the alkaloids Crotsparine and Sparsiflorine, isolated from Croton bomplandianum, against Pseudomonas aeruginosa. Mem. Inst. Investig. Cienc. Salud [online]. 2019, vol.17, n.1, pp.47-53. ISSN 1812-9528.  https://doi.org/10.18004/mem.iics/1812-9528/2019.017(01)47-053.

The synergistic activity of the alkaloids crotsparine and sparsiflorine, isolated from Croton bomplandianum Baill, was evaluated with the antibacterials gentamicin and ciprofloxacin against Pseudomonas aeruginosa, a microorganism frequently responsible for nosocomial infections. The checkerboard method was used. Combinations were found that had a synergic effect, achieving a reduction of 87.5% of the MIC of gentamicin, while for ciprofloxacin a reduction of 25.0% was observed. This opens interesting perspectives on the combined use of pure natural products and drugs in clinical use for the treatment of infections produced by this microorganism.

Keywords : crotsparine; sparsiflorine; Croton; Pseudomonas; gentamicin; ciprofloxacin.

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