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Memorias del Instituto de Investigaciones en Ciencias de la Salud

versão On-line ISSN 1812-9528


SEGOVIA, Edith Alba et al. Evaluation of the mutagenic / antimutagenic effects of Luehea divaricata in mice. Mem. Inst. Investig. Cienc. Salud [online]. 2016, vol.14, n.3, pp.102-106. ISSN 1812-9528.

The Luehea divaricata Mart. is a plant native, popularly known in Paraguay as "ovetîka'a" or "ovetîka'aPytá" of the region used as herbal medicines. The aim of this study was to investigate the protective effect of aqueous extract from the leaves of L. divaricata versus cyclophosphamide chemotherapy. The animals were divided in 4 groups and each group have 5 animals, Group I, negative control, which received 200 uL of water, orally; Group II, which received 200 uL of aqueous extract of L. divaricata; Group III, which received 200 uL of the aqueous extract of L. divaricata and cyclophosphamide, 50 mg / kg animal weight; Group IV, positive control, cyclophosphamide received 50mg / kg / animal weight. The aqueous extract of L. divaricata was orally administered and the treatment was administered for 48 hs, cyclophosphamide was administered intraperitoneal and had 24 hours of treatment. Bone marrow of the animals is removed and micronucleus assay was performed on all samples. The results indicated that aqueous extract of L. divaricata showed no mutagenic activity and when combined with the mutagen agent induces a reduction of up to 41% in the frequency of micronucleus, when compared to treatment with cyclophosphamide, suggesting a potential protective effect against toxic agents.

Palavras-chave : Luehea divaricata; micronucleus; protector effect.

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