Abstract

GUILLEN, Rosa et al. Drug induced crystalluria in the Emergency Laboratory: Report of two cases. Mem. Inst. Investig. Cienc. Salud [online]. 2016, vol.14, n.2, pp.106-109. ISSN 1812-9528.  https://doi.org/10.18004/Mem.iics/1812-9528/2016.014(02)106-109.

Certain drugs that are excreted in the urine, including antibiotics, could induce the formation of crystals when the dose used is high, the diuresis is low or the pH of the urine is acid. The events of drug induced crystalluria are rare and could be asymptomatic or could cause acute renal failure. In this report, we describe two cases: One of a 26-year-old woman with ampiciline crystalluria and a 8-year-old child with amoxiciline crystalluria, both registered at the Emergency Laboratory of the Central Hospital of the Instituto de Prevision Social. The analysis of the urinary sediment was made by conventional microscopy, and then the crystals were studied by polarized light microscopy and infrared spectroscopy achieving the exact identification of the chemical nature of the crystals. This is the first report of drug induced crystalluria in the country and shows the importance of the colaborative work between state institutions.

Keywords : Drug induced crystalluria; FTIR; Polarized light microscopy.

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