Abstract

ROJAS, Alejandra et al. Clinical, hematological and serological profile in suspected dengue patients at IICS-UNA, 2009-2013. Mem. Inst. Investig. Cienc. Salud [online]. 2016, vol.14, n.2, pp.68-74. ISSN 1812-9528.  https://doi.org/10.18004/Mem.iics/1812-9528/2016.014(02)68-074.

Dengue is one of the most important mosquito-borne diseases worldwide. The disease may present as asymptomatic, with a wide range of non-specific clinical manifestations or a certain percentage can result in severe cases. This observational, descriptive, cross-sectional study aimed to determine the clinical features, hematological parameters and the presence of IgM in 92 patients who attended to IICS-UNA with clinical suspicion of dengue from 2009 to 2013. The MAC-ELISA developed at IICS-UNA was used, clinical and epidemiological data were recorded through a survey and hematological parameters were determined. Positive results for IgM in 51/92 (55%) patients were obtained and negative results in 41/92 (45%). The most frequent clinical features were fever, headache, muscle and joint pains. Among patients with positive IgM, 14/51 (27%) reported abdominal pain, 19/51 (37%) reported lethargy or prostration and 20/51 (39%) reported having nausea and/or vomiting, 4/51(8%) had leucopenia, 10/51 (20%) decreased hematocrit values and 6/51 (12%) presented thrombocytopenia. Only 13/92 (14%) patients reported a previous DENV infection. Of the total, 4/92 (4%) presented some type of bleeding. The results of the study reinforce the importance of integrating all possible parameters: IgM detection, hematological and clinical profile of patients with suspected dengue to provide better diagnosis. It is also necessary to emphasize warning signs for a quick intervention to avoid complications.

Keywords : Dengue; symptoms; IgM; hematological profile.

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