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Memorias del Instituto de Investigaciones en Ciencias de la Salud

On-line version ISSN 1812-9528


ACOSTA COLMAN, Isabel et al. Clinical and laboratory manifstations in Systemic Lupus Erythematosus. Mem. Inst. Investig. Cienc. Salud [online]. 2016, vol.14, n.1, pp.94-109. ISSN 1812-9528.

Systemic Lupus Erythematosus (SLE) is a complex autoimmnune disease characterized by its ability to affect different organs, which determines different clinical manifestations observed during the course of the disease. It has been described that these manifestations have geographic or ethnic varations being generally less serious in patients of European descent than in those with African, Asian or Hispanic descents. Alterations of both the adaptative (T and B cells) and innate (Toll like receptorx-TLR) immnune systems contribute to the development of SLE. B cells have a role in the production of auto-antibodies (i.e. anti-DNA and anti-nucleosome antibodies) and some cytokines. Laboratory tests are invaluable when evaluating a patient with suspected autoimmune disease. The results can confirm the diagnosis, estimate the severity of the disease, assess prognosis and are extremely useful for monitoring the activity of SLE.

Keywords : clinical manifestations; systemic lupus erythematosus; laboratory tests.

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