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Memorias del Instituto de Investigaciones en Ciencias de la Salud

On-line version ISSN 1812-9528

Abstract

BOBADILLA, Maria Liz et al. Molecular Detection of High Risk Human Papillomavirus in following women treated for squamous intraepithelial lesion. Mem. Inst. Investig. Cienc. Salud [online]. 2016, vol.14, n.1, pp.64-69. ISSN 1812-9528.  https://doi.org/10.18004/Mem.iics/1812-9528/2016.014(01)64-069.

Cervical cancer is the leading cause of cancer death in women in developing country. Persistent infection with human papillomavirus (HPV) is a necessary factor in premalignant lesions and cervical cancer. The Pap smear is the method most commonly used to detect the cervical cancer and its combined with the detection of viral DNA six months post-treatment increases effectiveness to identify women treated in risk with residual/recurrent lesion. The aim was to describe the frequency of high-risk HPV (HR) in treated women for squamous intraepithelial lesion (SIL) who attended the Cervical Pathology Service of Hospital San Pablo from January to December/2014. It is cross sectional, descriptive study which included 80 patients who attended the service for post-treatment control. The 4800 Cobas HPV Test (Roche) was used, which detects HPV-16 and 18, and a pool of 10 HR-HPV (31,33,35,39,45,51,52,56,58,59) and two "probable" high risk (66,68). Viral infection was found in 7.5% (6/80) of patients treated; identifying HPV-16 in 3/6 of positive cases. In Paraguay there is a high incidence of pre-neoplastic lesions and cervical cáncer remains a public health problem. The observed data suggest that the use of this system for viral detection can lead to optimize the post-treatment monitoring and the identification of HPV-16 and 18 could contribute to the selection of patients at increased risk of developing cervical injury should undergo to frequent and careful monitoring.

Keywords : Human Papilloma Virus; squamous intraepithelial lesion (SIL) COBAS 4800 HPV Test; post-treatment control.

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