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Memorias del Instituto de Investigaciones en Ciencias de la Salud

versão On-line ISSN 1812-9528


BOBADILLA, ML et al. Molecular detection of high oncogenic risk human papiloma virus in cervical samples. Central Laboratory of Public Health: First results. Mem. Inst. Investig. Cienc. Salud [online]. 2015, vol.13, n.1, pp.17-23. ISSN 1812-9528.

Cervical cancer is the leading cause of cancer death in women in developing countries, with an incidence rate of 34.2 per 100,000 women and 15.7 deaths per 100,000 women in Paraguay. The sensitivity of cytology is 30-60% while molecular detection of Human Papilloma Virus (HPV) in cervical samples is over 90% for cervical intraepithelial neoplasia grade 2 (CIN II) or more. The aim of this study was to describe the frequency of detection of high-risk HPV (HR) and their distribution by age in women who attended the Hospital San Pablo, from May to August 2013. One hundred seventy cervical samples from patients who agreed to participate by signing an informed consent. The 4800 Cobas system HPV Test (Roche), which detects the HR-HPV genotypes 16 and 18, a pool of 10 HR-HPV (31,33,35,39,45,51,52,56,58,59) and two "probable" high risk (66.68). The frequency of HR-HPV infection was 16%, the infection decreased with age and the highest number of cases occurred in women under 30 years. HPV-16 was found in all age groups. This is the first report about detection of DNA HR-HPV in the LCSP and it showed that prevention and control of cervical cancer is a public health priority in the country by the large burden of the disease as evidenced by its high incidence and mortality.

Palavras-chave : Virus Papiloma Humano; COBAS 4800 HPV test; muestras cervicales.

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