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Memorias del Instituto de Investigaciones en Ciencias de la Salud

versão On-line ISSN 1812-9528


CARDOZO SEGOVIA, FM et al. Molecular detection of multiple infections in women with and without cervical lesion positive for high risk human papillomavirus, period 2007-2011. Mem. Inst. Investig. Cienc. Salud [online]. 2012, vol.10, n.2, pp.05-12. ISSN 1812-9528.

Cervical cancer caused by human papilloma virus (HPV) is the third most common cancer type in women worldwide. The objective of this work was to determine the frequency of multiple infections in women positive for high oncogenic risk HPV by polymerase chain reaction followed by reverse hybridization, Hybrid Capture II, according to severity of the squamous intraepithelial lesion (SIL), relative viral load and age in the 2007-2011 period. This cross-sectional study included 123 women who attended the Health Sciences Research Institute (IICS in Spanish), 18 without lesion (NSIL), 78 with low-grade SIL (LSIL) and 27 with high-grade SIL (HSIL). Multiple infections were detected in 37/123 women (30.1%). NSIL women had lower frequency of multiple infections (5.6%) than women with SIL (34.3%) (p = 0.03). There was no increase of the frequency of multiple infections with the severity of the lesion, presenting women with LSIL a frequency of 34.6% and women with HSIL 33.3%. There was no significant difference between relative viral load in multiple and simple infections, suggesting that in multiple infections may be only one type of HPV that is replicating and causing a productive infection. In addition, we observed a high frequency of multiple infections (75%) in women under 30 years old. Finally, the results suggest that multiple infections could orient towards the presence of SIL presence but not the severity of the cervical lesion.

Palavras-chave : multiple infections; human papillomavirus; Hybrid Capture II; relative viral load.

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