Memorias del Instituto de Investigaciones en Ciencias de la Salud
On-line version ISSN 1812-9528
ESPINOLA CANO, AF et al. Acute myeloid leukaemia with t(8; 21)(q22; q22). Case report. Mem. Inst. Investig. Cienc. Salud [online]. 2011, vol.9, n.2, pp. 64-71. ISSN 1812-9528.
ABSTRACT Acute myeloid leukemia is a haematopoietic neoplasia characterized by clonal proliferation of immature blasts in bone marrow, interfering with its normal functions. Overall survival is about 35% affecting mainly male adults over 60 years old and infants under one year old. Genetic translocation t(8;21)(q22;q22) is a recurrent finding and involves RUNX1 and RUNX1T1 genes. The detection of this genetic translocation is relevant to the diagnosis and prognosis of the disease. The objective of this work is to report two cases of acute myeloid leukaemia in 14 and 24 years old male patients with typical clinical, laboratorial and morphological findings but with unusual appearing ages, emphasizing the good prognosis from the genetic point of view of this translocation in both cases.
Keywords : myeloid leukemia; genetic translocation; cytogenetic analysis; prognosis.