Memorias del Instituto de Investigaciones en Ciencias de la Salud
versión On-line ISSN 1812-9528
GUILLEN, R et al. Evaluation of lithogenic parameters in urolithiasis patients attending the Instituto de Investigaciones en Ciencias de la Salud in 2009. Mem. Inst. Investig. Cienc. Salud [online]. 2010, vol.8, n.1, pp. 14-21. ISSN 1812-9528.
ABSTRACT Kidney stones are formed when concentration of urinary components reach such a level in which crystallization is possible. Although clinical manifestations of all kidney stones are similar, they differ in composition, pathogenesis and treatment. Metabolic background is associated to urolithiasis and metabolic evaluation is essential to establish specific treatment and avoid recurrences. In this cross-sectional observational descriptive study, we determined the levels of analytes with lithogenic or crystallization inhibitor potential in blood and urine samples of 40 patients, male and female, with diagnosis of urolithiasis that attended the Department of Clinical Analysis of the IICS from June to October, 2009. Additionally, we describe the most frequent clinical manifestations present in these patients. The study protocol was submitted and approved by the IICS scientific and ethic committees. Of the total number of patients, 52.5% were children (n=21, 9 ± 4 years old) and 47.5% adults (n=19, 35 ± 17 years old). Alterations in the values of the potentially lithogenic parameters were detected in 48% of the children and 87% of the adults. The most frequent metabolic abnormalities were hypocitraturia and hypercalciuria in both groups. The most frequent symptoms were colics, hematuria and fever. Half of the patients referred a family history of urolithiasis. Overweight was detected in 58% of the adult patients. Water intake lower than 2 litres per day was referred by 90% of children and 47% of adults respectively. These findings point out the importance of the metabolic evaluation as a tool to orient adequate diagnosis and treatment.
Palabras llave : Urolithiasis; metabolic evaluation; lithogenic parameters.