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Memorias del Instituto de Investigaciones en Ciencias de la Salud

versión On-line ISSN 1812-9528

Resumen

RECALDE CANETE, A. Lynch syndrome. Prevalence, clinical characteristics and treatment. Mem. Inst. Investig. Cienc. Salud [online]. 2007, vol.5, n.2, pp.32-37. ISSN 1812-9528.

Hereditary nonpoliposis colorectal cancer o Lynch syndrome has an autosomal dominant transmission with 85% penetrance representing about 5% of all colorectal cancer. The present study was carried out to establishes the prevalence of this syndrome and compare its clinical characteristics and treatment with patients having sporadic colorectal cancer.This is a descriptive observational study with an analytical component where all the patients with colorectal cancer diagnosed by histopathology that concurred to the Surgical Service of the Hospital de Clinicas and Instituto de Previsión Social between June 1999 and April 2005 were included. The patient or a first degree relative was contacted to evaluate family record of other neoplasias to get the necessary information for the diagnosis of Lynch syndrome using the Amsterdam II criteria. Three hundred twenty four patients with colorectal cancer were study and the prevalence of Lynch syndrome was 2.7% (IC 95% 0.9-4.5). The median age was significantly lower and the presence of synchronic and metachronic tumors was significatively higher in patients with Lynch syndrome than in patients with sporadic colorectal cancer. There was any significant difference in the tumor stage and no difference in the type of surgical resection was found between both groups of patients. The prevalence of the Lynch syndrome in patients with colorectal cancer was low, its clinical characteristics were significatly different from those of the sporadic colorectal cancer while the type of surgical resections were not different between the two groups.

Palabras clave : Lynch syndrome; colorectal cancer; hereditary colorectal cancer.

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