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Memorias del Instituto de Investigaciones en Ciencias de la Salud

On-line version ISSN 1812-9528

Abstract

PRUDENTE, I; CASTRO, M  and  ALALLON, W. Correlation between serum concentrations of apolipoprotein B and LDL cholesterol in a population sample. Usefulness of apolipoprotein B to value atherogenic risk. Mem. Inst. Investig. Cienc. Salud [online]. 2006, vol.4, n.1, pp.34-38. ISSN 1812-9528.

Apolipoprotein B (apoLp B) is the main protein component of the cholesterol delivery route to peripheral tissues. It has been proposed as a better predictor of cardiovascular disease than LDL cholesterol. The aims of this study were to determine the serum concentration of apoLp B, its relation with LDL cholesterol, its "desirable" and "high risk" limits and to evaluate patients with hyperapolipoproteinemia B and cLDL below risk values. A total of 265 subjects were randomly selected from a population referred for lipid studies to the Hospital Universitario. We measured concentrations of apoLp B, total cholesterol, triglycerides, HDL cholesterol and calculated LDL cholesterol. When LDL cholesterol was < 130 mg/dl, apoLp B value was < 98 mg/dl, which corresponds to a "desirable" limit. When LDL cholesterol was >160 mg/dl, apoLp B value was > 120 mg/dl, corresponding to a "high risk" limit. Of all patients with LDL cholesterol < 160 mg/dl (n=202), 3.5% had apolipoprotein B > 120 mg/dl. We found a desirable apoLp B value of 98 mg/dl and high risk apoLp B value of 120 mg/dl. In the patients with LDL cholesterol below 160 mg/dl, 3.5% showed apoLp B values above 120 mg/dl and they were considered patients with hyperapolipoproteinemia B. In this population with suspicion of coronary disease but without risk LDL cholesterol values, the measurement of apoLp B, as an emerging coronary risk factor, is strongly recommended.

Keywords : Apolipoprotein B; hyperapolipoproteinemia B; atherogenic risk.

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