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Memorias del Instituto de Investigaciones en Ciencias de la Salud

On-line version ISSN 1812-9528

Abstract

D´ARRIGO, M et al. Apolipoprotein E allelic frequency in a native population. Mem. Inst. Investig. Cienc. Salud [online]. 2006, vol.4, n.1, pp.25-27. ISSN 1812-9528.

The polymorphism of apolipoprotein E (apoE) is originated by e2, e3 and e4 alleles. Ethnic origin has demonstrated to be a decisive factor for ApoE genotype. There are few studies about its distribution. We carried out this explorative study of the apoE genotype frequency (AF) in a native population (NP) born in the Chaco province and emigrated to Rosario (Argentina) and/or descendants in order to compare it with a Caucasian Argentinean population (CP), a fact that has not been reported yet. To compare the allelic frequency of both populations (NP n: 71. 1 to 45 yr and CP n: 56.5 to 17 yr), the sample size was calculated to achieve a representative estimation of total population with a confidence interval of 95%. Samples were randomly collected from individuals that accepted to participate and signed an informed consent. The molecular characterization was made by ASA-PCR. To compare the AF of both populations, the hypothesis assay of a proportion under a normal theory was carried out. The allelic frequencies (AF) in the PC were: e3 0.786 (IC 95% 0.679-0.893), e4 0.178 (IC 95% 0.078-0.278), e2 0.036 (IC 95% 0.000-0.084). While FA in PA were e3 0.880 (IC 95% 0.804-0.956), e4 0.084 (IC 95% 0.021-0.147) and e2 0.035 (IC 95% 0.000-0.075). Significant differences were observed in the AF of e3 and e4 among the different populations. The sample size and sampling procedure, ethnia, environmental factors, and lab protocols could have contributed to the diversity of the results.

Keywords : ApoE genotype; coronary disease; native population.

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