Introduction:

In the last two decades, the role of Helicobacter pylori infection in the genesis of allergic diseases has been explored, showing data supporting the idea that it could play an important role in the development of allergy.

Objective:

To identify the association between Helicobacter pylori and allergic diseases.

Materials and methods:

This was a prospective case-control study carried out at the “Santa Cruz” Clinic (Barquisimeto, Lara State, Venezuela), between June 2022 and June 2023, where 65 children with allergic diseases were compared with 130 healthy controls, aged between 2 and 15 years old, who presented for routine outpatient consultation. Demographic variables, cesarean delivery, family history of allergies, breastfeeding time, exposure to tobacco smoke, pets, obesity, percentage of eosinophils and a positive Helicobacter pylori test in feces were compared with the presence of allergic diseases as a dependent variable. Bivariate analysis and binary logistic regression were used.

Results:

Factors significantly associated with allergic diseases were: family history of allergy, breastfeeding time of less than 12 months, and positive Helicobacter pylori test in feces. The following were identified as independent predictors associated with allergic diseases: family history of allergy (OR=2.345; 95%CI: 1.245 - 4.416; p = 0.008) and positive Helicobacter pylori test in stool (OR=2.072; 95%CI: 1.090 - 3.939; p = 0.026).

Conclusions:

The presence of a family history of allergy and a positive Helicobacter pylori test in stool were identified as independent variables associated with allergic diseases.

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