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Pediatría (Asunción)

versão On-line ISSN 1683-9803

Resumo

AGUILAR-CAMPOS, Jesús Abraham et al. Elevated cystatin C prevalence in overweight and obese patients in northwestern Mexico. Pediatr. (Asunción) [online]. 2021, vol.48, n.3, pp.195-202. ISSN 1683-9803.  https://doi.org/10.31698/ped.48032021007.

Introduction:

in recent years an increase has been reported in the prevalence of childhood obesity, which is a risk factor for chronic degenerative diseases such as Chronic Kidney Disease; therefore, endogenous biomarkers are needed to detect alterations in glomerular filtration, Cystatin C being one of them.

Objective:

To identify the frequency of elevated Cystatin C in overweight and obese patients in northwestern Mexico.

Materials and Methods:

a group of infants aged 6 to 12 years was studied, who according to anthropometry were classified as normal weight, overweight or obesity. Somatometry and Cystatin C levels were obtained from each of them to calculate glomerular filtration rate and classify renal function, and an association between these two conditions was sought using the chi-square test.

Results:

of a group of 80 patients, 51.3% were overweight / obese; Of these, 46.3% had high levels of Cystatin C, according to the reference range proposed by Filler 2003. The mean Glomerular Filtration Rate (GFR) in the overweight / obese group was 103.1 ml / min / 1.73 m2, compared to the normal weight group of 121.2 ml / min / 1.73 m2. The frequency of high levels of Cystatin C in the overweight / obese population was 62.9% compared to 26.6% in normal weight.

Conclusions:

Children from 6 to 12 years of age with excess weight have a higher frequency of high levels of Cystatin C.

Palavras-chave : Childhood obesity; cystatin c; glomerular filtration rate; chronic kidney disease..

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