Resumo

ALONSO, Sonia  e  JIMENEZ ROLON, Hassel Jimmy. Clinical and Epidemiological Characteristics of Patients with Sepsis in a Pediatric Intensive Care Unit in Paraguay. Pediatr. (Asunción) [online]. 2013, vol.40, n.3, pp.227-233. ISSN 1683-9803.

Introduction: Sepsis is a significant cause of morbidity and mortality in children, and one of the primary causes for admission to pediatric intensive care units. Objective: We undertook to describe the clinical and epidemiological characteristics of patients with sepsis hospitalized in the pediatric intensive care unit of the Hospital de Clínicas in San Lorenzo, Paraguay. Methods: We conducted a retrospective, observational, and descriptive study from July to December 2010 on hospitalized patients aged 28 days to 17 years who developed sepsis. Results: We included 71 of 124 admitted patients. Of these, 60% were referred from the general care unit of the hospital and 55% from other areas of the country, while 52% were male and 49% under age 2 years; 32.4% showed a PRISM score greater than 10, 43.7% presented septic shock, 35.2% multiple organ failure, in 34% infection was nosocomial, and underlying pathology in 75%, predominantly malnutrition (53.5%), leukemia, and solid tumors. Average hospital stay was 9.2 days. Focus of the infection was respiratory in 59% of cases, and a microorganism was isolated in 34%, most often Pseudomona and Klebsiella. More than 3 expansions were performed on 73%, 87% were given inotropic agents, and 65% MV. ARDS occurred in 21% of patients with septic shock. Mortality was 18.3%. Of those who died, 62% were male, 38.5% infants, 46% showed malnutrition, 85% underlying pathologies, 77% pulmonary infection, and 61.5% ARDS. Multiple organ failure was the cause of death in 85% of patients. Conclusions: Mortality due to sepsis in this pediatric intensive care unit occurred most often in infants, and with pulmonary infectious focus, while other associated risk factors were malnutrition or an additional underlying pathology. The rate of mortality found was significant, probably due to delayed diagnosis and hospitalization and the high frequency of complications.

Palavras-chave : Sepsis; epidemiology; risk factors; pediatric intensive care units.

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