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Revista Paraguaya de Reumatología
On-line version ISSN 2413-4341
Abstract
VALLEE-VASQUEZ, Maximar Josefina; PEREZ, Gerson Jhair Méndez and SILVA, Yurilís J. Fuentes-. Extra-articular manifestations in patients with rheumatoid arthritis. Rev. parag. reumatol. [online]. 2024, vol.10, n.1, pp.7-13. Epub June 27, 2024. ISSN 2413-4341. https://doi.org/10.18004/rpr/2024.10.01.7.
Introduction:
Rheumatoid arthritis (RA) is a chronic inflammatory, autoimmune disease, characterized by chronic, additive, symmetrical polyarthritis, which can present with extra-articular manifestations (ExAM), associated with greater morbidity and mortality. Objective: to describe the most frequent ExAM in RA. Methods: a descriptive, cross-sectional and retrospective study was carried out to review the medical records of patients diagnosed with RA, during the period December 2011-January 2022. Results: 150 patients with RA participated, with an average age of 53.7±12.5 years, the predominant sex was female with 84.6%, the evolution time of RA was 7.2±8.9. years; Regarding serological characteristics, 91.1% had positive Rheumatoid Factor and 76.9% had positive antibodies against cyclic citrullinated peptides. Both upon admission and at the last consultation, patients presented some extra-articular manifestation (ExAM), 61.3% and 70%, respectively, with the most frequent being chronic anemia (at admission 44.6% and at last consultation 50.6%), followed by rheumatoid nodules (at admission with 8% and at the last consultation 9.3%). Conclusions: ExAM occurred in 70% of patients, the most frequent being anemia and rheumatoid nodules. These data show the changes in the frequency of ExAM in the disease over time.
Keywords : Rheumatoid arthritis; extra-articular manifestations; rheumatoid factor.