Resumo

APARICIO-VERA, Luis Alberto  e  GARCIA-HERRERA, Iris Paola. POMP GENE: Role in mechanisms of autoimmunity and inflammation. Rev. parag. reumatol. [online]. 2024, vol.10, n.1, pp.30-36.  Epub 27-Jun-2024. ISSN 2413-4341.  https://doi.org/10.18004/rpr/2024.10.01.30.

This publication addresses autoimmunity, and defective mechanisms in immunological tolerance as well as their connection to autoimmune diseases. It focuses on the POMP protein and the ubiquitin-proteasome system, explaining its role in protein degradation and its involvement in the formation of the immunoproteasome. The structure of the proteasome, ubiquitination, and the influence of POMP on the inflammatory response are detailed, highlighting the formation of the immunoproteasome under interferon stimulation. Additionally, the text explores the implication of POMP in autoinflammatory processes, such as proteasome-associated syndromes, and mentions its association with autoimmune diseases, including systemic lupus erythematosus. Clinical cases are described to underscore the significance of POMP in autoimmunity.

Palavras-chave : POMP gene; proteosome; ubiquitin; autoimmunity..

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