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Revista Paraguaya de Reumatología
versión On-line ISSN 2413-4341
Resumen
SERPA, Oscar Vicente Vergara et al. Sjögren's syndrome: identification of new biomarkers and molecular mechanisms involved in its pathophysiology. Rev. parag. reumatol. [online]. 2024, vol.10, n.1, pp.22-29. Epub 27-Jun-2024. ISSN 2413-4341. https://doi.org/10.18004/rpr/2024.10.01.22.
Introduction:
Sjögren's Syndrome (SS) is a systemic autoimmune disease that primarily affects the exocrine glandular system, leading to abnormal lacrimal and salivary gland function. Objective: To provide an update on identifying new biomarkers and molecular mechanisms involved in the pathogenesis of SS. Method: Narrative review of the literature in various databases, searching for terms included in the MESH and DeCs thesauri, for articles published since 2018. Results: We present evidence highlighting the identification of new biomarkers and mechanisms involved in the pathogenesis of SS, describing pathways of B lymphocytes, cathepsin S, cystatin C, modified C-X3-C chemokine ligand 1, thymus activation-regulated chemokine, T cells, bone morphogenetic protein 6, oxytocin receptor stimulation, zinc receptor, and calponin-3. Conclusion: Advances in technology facilitate detailed analysis of the genetics and pathogenesis of SS, driving the development of specific therapies. The search for non-invasive biomarkers is driven by the limitations of existing methods and the invasiveness of salivary gland biopsies, promising diagnostic and therapeutic improvements.
Palabras clave : Sjögren’s syndrome; Xerostomia; Biomarkers; Physiopathology; Genetic; B-Lymphocytes; Autoantibodies; Autoimmunity..