Abstract

BENITEZ, Irene et al. Disseminated histoplasmosis with skin lesions and osteomyelitis in a child with acute lymphoblastic leukemia undergoing maintenance treatment. Pediatr. (Asunción) [online]. 2019, vol.46, n.1, pp.38-42. ISSN 1683-9803.  https://doi.org/10.31698/ped.46012019007.

Histoplasma capsulatum usually manifests as a disseminated infection in immunocompromised patients. Osteomyelitis due to H. capsulatum is rare and difficult to diagnose. We present an unusual case of disseminated histoplasmosis, caused by H. capsulatum var. capsulatum, with lesions in skin, mucous membranes and osteomyelitis in a 10-year-old boy with acute lymphoblastic leukemia undergoing low-dose oral methotrexate treatment, who had an adequate response to Amphotericin B and maintenance treatment with Itraconazole.

Keywords : histoplasmosis; osteomyelitis; immunocompromised; methotrexate; children.

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